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亚硝酸钠和醋酐氧化示例

来源: 作者: 2018-10-24 18:17:44

亚硝酸钠和醋酐氧化示例

一个较实用的合成醛的方法,反应一般在室温下进行,反应时间较短,可氧化大部分伯醇、烯丙醇和苄醇,而且产率较高,副反应较少。一般仲醇很难反应,可能会生成亚硝酸酯。

反应示例

A typical procedure for oxidation of 4-nitrobenzylalcohol: a mixture of NaNO2(1035 mg

亚硝酸钠和醋酐氧化示例

, 15mmol) and 4-nitrobenzyl alcohol (5 mmol) in acetic anhydride (2 mmol) was stirred. A spontaneous exothermic reaction took place which was controlled by cooling the mixture in ice. After completion of the reaction (TLC), the product was extracted with ether (2 10 ml). Removal of the solvent under reduced ded crude 4-nitrobenzaldehyde which was further by column chromatography(petroleum ether–ethyl acetate, 9 : 1).

Reference:J. Chem. Soc., Perkin Trans. 1, 2000,3559–3560

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